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| Campos,Viviane Aparecida Costa; Santos Júnior,Helvécio Martins dos; Oliveira,Denilson F; Carvalho,Hudson Walace Pereira de; Machado,Alan Rodrigues Teixeira; Tirelli,Aline Auxiliadora. |
| To contribute to the development of antibacterial products from propolis produced by native Brazilian bees, twenty-nine samples of propolis collected from hives in the state of Minas Gerais, Brazil, were screened for in vitro activity against Aeromonas hydrophila, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus. Among the samples from native Brazilian bees, only that from Frieseomelitta varia (Lepeletier, 1836) inhibited in vitro bacterial growth. Consequently, this propolis underwent fractionation by chromatographic methods monitored through Agar-diffusion assays with these bacteria, which resulted in the isolation and identification of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C), which showed MIC of 62.5 and 250 µg/mL against... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artepillin C; Stingless bees; Antibiotic. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542011000600002 |
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| PAZIN,WALLANCE M.; SANTOS,SUIKINAI N. DOS; QUEIROZ,SONIA C.N.; BAGATOLLI,LUIS A.; SOARES,ADEMILSON E.E.; MELO,ITAMAR S. DE; ITO,AMANDO S.. |
| Abstract: We have established how natural compounds from green propolis collected by the species Apis mellifera act against the growth of Pythium aphanidermatum. On the basis of mass spectrometry (Q-ToF MS), we determined that Artepillin C, the major constituent of green propolis, underlies the effect and displays activity against P. aphanidermatum at a minimal inhibitory concentration of 750 µg.mL-1. Biophysical studies based on model membranes showed that this inhibitory effect may be linked with a membrane-related phenomenon: Artepillin C increases the permeability of membranes with relatively high fluidity in their lateral structure, a feature that is in line with the lipid composition reported for the cytoplasmic membrane of P. aphanidermatum.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Green propolis; Artepillin C; Fungicide; Pythium aphanidermatum; Model membranes. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300617 |
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| Pazin,W.M.; Vilanova,N.; Voets,I.K.; Soares,A.E.E.; Ito,A.S.. |
| It has been hypothesized that the therapeutic effects of artepillin C, a natural compound derived from Brazilian green propolis, are likely related to its partition in the lipid bilayer component of biological membranes. To test this hypothesis, we investigated the effects of the major compound of green propolis, artepillin C, on model membranes (small and giant unilamelar vesicles) composed of ternary lipid mixtures containing cholesterol, which display liquid-ordered (lo) and liquid-disordered (ld) phase coexistence. Specifically, we explored potential changes in relevant membrane parameters upon addition of artepillin C presenting both neutral and deprotonated states by means of small angle X-ray scattering (SAXS), differential scanning calorimetry... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artepillin C; Green propolis; Model membranes; Giant unilamellar vesicles; SAXS; DSC. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300610 |
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